Lessons learned from mouse models of hemolytic transfusion reactions

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Hemolytic Transfusion Reactions.

SUMMARY: The risk of hemolytic transfusion reactions (HTRs) is approximately 1:70,000 per unit. Acute HTRs occurring during or within 24 h after administration of a blood product are usually caused by transfusion of incompatible red blood cells (RBCs), and, more rarely, of a large volume of incompatible plasma. Delayed HTRs are caused by a secondary immune response to an antigen on the donor's ...

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Hemolytic transfusion reactions

A hemolytic transfusion reaction (HTR) is the accelerated clearance or lysis of transfused red cells because of immunologic incompatibility. Although they may at times have similar clinical presentations, HTR is distinguished from autoimmune hemolysis or nonimmune causes of shortened survival of transfused red cells. HTR may occur when antigen-positive red cells are transfused to a patient with...

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Delayed hemolytic transfusion reactions.

Delayed hemolytic transfusion reactions continue to occur in spite of the use of all of the currently available techniques of antibody detection. Both low titers of the antibodies and dosage effects appear to contribute to the failure of detection. A rapid anamnestic response can occur with transfusion of the appropriate antigen. The clinical as well as the laboratory presentation of delayed he...

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Hemolytic and pseudo-hemolytic transfusion reactions: an overview of the hemolytic transfusion reactions and the clinical conditions that mimic them.

When a reaction occurs during or after the transfusion of a blood product, those involved in the care of that patient tend to think first of an immunological evenł. l However, many transfusion reactions may not be immunologically mediated. The differential diagnosis of a transfusion reaction should include the many nonimmune conditions that can lead to the destruction of either donor or recipie...

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ژورنال

عنوان ژورنال: Current Opinion in Hematology

سال: 2008

ISSN: 1065-6251

DOI: 10.1097/moh.0b013e328311f40a